Titlebook: Mechanism of Action of Antieukaryotic and Antiviral Compounds; Fred E. Hahn Book 1979 Springer-Verlag Berlin · Heidelberg 1979 Antibiotiku

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不能仁慈

Antitumor Platinum Compounds,ion against Sarcoma 180 and Leukemia L1210 (. et al., 1969; . and . ., 1970), a viral-induced reticulum cell sarcoma in mice (., 1970), the Dunning ascitic leukemia, Walker 256 carcinosarcoma (. et al., 1970),and a DMBA-induced mammary carcinoma (., 1971) in rats.

搖擺

,9-β-D-Arabinofuranosyladenine (AraA),d by Parke, Davis and Company (British Patent No. 1,159,290) as an antibiotic produced by .. Chemical synthesis, initially achieved through the conversion of a xylonucleoside to araA (. et al., 1960; . et al., 1962), was subsequently accomplished on a larger scale by the condensation of 2,3,5-tri-O-

熔巖

8-Azaguanine,sed this inhibition. In 1949 . and . confirmed these findings when the analog inhibited multiplication of .. Subsequently, several investigators proved 8-azaguanine to be an inhibitor of the chick embryo (. et al., 1950), the Lucerne mosaic virus (., 1952), the . virus (., 1952), human glioblastomas

Myelin

Bleomycin,ntineoplastic antibiotic, bleomycin. ., the discoverer of bleomycin (. et al., 1966) has written several reviews dealing primarily with the chemistry, structure, in vitro, and in vivo studies of bleomycin (., 1975, 1976). Other articles dealing more specifically with the extracellular reaction betwe

insomnia

Diphtheria Toxin and Exotoxin A from ,,al toxins have been studied in greater depth, and new toxins have been discovered as well. As a result of the expanded interest and efforts there now exists a substantial and rapidly growing body of knowledge about the structures and activities of bacterial toxins from which one can begin to make me

exceptional

漂泊

2-Hydroxy-3-Alkyl-1,4-Naphthoquinones,of the antimalarial drug quinine. Faced with entirely inadequate supplies of quinine coupled with the grim prospect of waging tropical warfare in some of the world’s worst malaria-infested regions, the Allied Powers instituted a comprehensive program of research in the chemotherapy of malaria. This

壓倒

Hydroxystilbamidine,midine, berenil, etc.), it shows strong activity against bacteria, protozoa, and fungi. It is clinically used in systemic mycosis, mainly North American blastomycosis, visceral leishmaniasis, and secondarily in prophylaxis and treatment of African trypanosomiasis, and in cases of malignancy, e.g., m

Endometrium

,5-Iodo-2′-Deoxyuridine,e base analogs was initiated by . et al. (1945) and extended by . et al. (1949). The clinical potential of base analogs, whether halogenated or not, has been well recognized in chemotherapy. Furthermore, such compounds have proven to be powerful tools for elucidation of many intricate biochemical ev