Titlebook: Mechanism and Genetic Susceptibility of Neurological Disorders; Andleeb Khan,Mashoque Ahmad Rather,Ghulam Md Ashra Book 2024 The Editor(s)

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Etiology of Ataxia: A Mechanistic Insight of Autoimmune, Toxicity, and Genetic Approach,lude pathogenic repeat extensions (CAG, CTG, GAA), DNA repair anomalies, gene-sequence alteration, point mutations, and mode of inheritance transmission. Additionally, the role of degenerative ataxia concerning multiple system atrophy and idiopathic late-onset cerebellar ataxia-related neurological

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miRNA Dysregulation in Schizophrenia,hizophrenia, are known to implicate aberrant miRNAs expression and malfunction in their pathogenesis. This study shows that in schizophrenia, the levels of mature miRNA present in the cerebral cortex as well as in peripheral blood mononuclear cells (PBMCs) were altered. In this chapter, we summarize

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Axonal Degeneration, Impaired Axonal Transport, and Synaptic Dysfunction in Motor Neuron Disorder,(PMA). These diseases reflect symptoms of muscle cramps, dysphagia, spasticity, muscle weakness, atrophy, disturbance of neuropsychiatric behavior, and loss of homeostasis. There is a strong correlation between MNDs and axonal transport impairment, as evidence suggests the defective anterograde and

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Genetic Modulators in Amyotrophic Lateral Sclerosis,iple factors contributing to the development of ALS, including defects in the metabolism of RNA and DNA, disturbance in DNA repair mechanism, protein homeostasis dysfunction, damage in nucleocytoplasmic transport, oxidative stress (OS), excitotoxicity, axonal transport alteration, neuroinflammation,

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Modulators and Poststroke Behavioral Changes,equently experience emotional and behavioral changes, which includes irritability, cognitive impairment, disability, inattention, disorientation, and feelings of anger, anxiety, or depression. Despite a plethora of neuroscientific initiatives and therapeutic efforts, several remedial pages are still

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Gene Editing Tool for Neurodegenerative Diseases,or addressing these challenges. Emerging gene-editing tools (GETs), such as CRISPR-Cas9 and zinc finger nucleases (ZFNs), offer promising potential for correcting defective genes or DNA, leading to the restoration of lost neural function and connectivity. Furthermore, the integration of GETs with st

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Lumbar Disc Disease: An Overview, the spine, bad posture, weight gain, and inheritance, can be linked to the cause of LDS. Low backache, leg discomfort, sensations of numbness or tingling in the lower extremities or feet, weaknesses, and trouble walking or standing are some of the signs of LDS. Diagnosis of LDS typically involves i

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