Titlebook: Mass Spectrometry Imaging of Small Molecules; Lin He Book 2015 Springer Science+Business Media New York 2015 MALDI-MS.biological metabolom

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Vulnerable

Automated Cell-by-Cell Tissue Imaging and Single-Cell Analysis for Targeted Morphologies by Laser Aing is performed by sampling on a predefined rectangular grid that does not reflect the natural cellular pattern of the tissue. Delivering laser pulses by a sharpened optical fiber in laser ablation electrospray ionization (LAESI) mass spectrometry (MS) has enabled the direct analysis of single cell

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Nanostructure Imaging Mass Spectrometry: The Role of Fluorocarbons in Metabolite Analysis and Yocto imaging capabilities for small molecules, metabolites, drugs, and drug metabolites. Specifically, laser desorption from the nanostructure surfaces results in efficient energy transfer, low background chemical noise, and the nondestructive release of analyte ions into the gas phase. The modification

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Ventilator

Nanoparticle-Assisted Laser Desorption/Ionization for Metabolite Imaging,tides, nucleic acids, lipids, and drug molecules. To expand the capabilities of MALDI-IMS, we have established an imaging technique using metal nanoparticles (NPs) to visualize metabolites, termed nanoparticle-assisted laser desorption/ionization imaging mass spectrometry (nano-PALDI-IMS). By utiliz

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hysterectomy

Laser Desorption Postionization Mass Spectrometry Imaging of Biological Targets,solid surface. This technique has been applied to study a wide variety of molecular analytes in biological systems, but is not yet available in commercial instruments. For this reason, a generalized protocol is presented here for the use of LDPI-MS imaging to detect small molecules within intact bio

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Data Processing and Analysis for Mass Spectrometry Imaging,the protocol and methods for data processing, visualization, and statistical analysis, with related techniques and tools available presented. Examples are given with data collected for a 3D MS imaging of a mouse brain and 2D MS imaging of human bladder tissues.

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Sample Preparation for 3D SIMS Chemical Imaging of Cells,to characterize them in their native state, free of chemical or physical changes. Here, we describe the four most widely used sample preparation methods for cellular imaging using ToF-SIMS, and provide guidance for data collection and analysis procedures.