Titlebook: Mass Spectrometry Imaging; Principles and Proto Stanislav S. Rubakhin,Jonathan V. Sweedler Book 2010 Springer Science+Business Media, LLC 2

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Quantitative Imaging of Chemical Composition in Single Cells by Secondary Ion Mass Spectrometry: Cisof cells with anticancer drug, cisplatin. Cisplatin, .-diamminedichloridoplatinum ii (CDDP), is widely used for the treatment of many malignancies, including testicular, ovarian, bladder, cervical, head and neck, and small cell and non-small cell lung cancers. The possibility of renal injury by cisp

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Cellular Imaging Using Matrix-Enhanced and Metal-Assisted SIMSctly in tissue sections, single cells, and many other biological surfaces. We describe here the steps required to retrieve the molecular information from tissue sections using matrix-enhanced (ME) and metal-assisted (MetA) secondary ion mass spectrometry (SIMS). Surface metallization by plasma coati