Titlebook: Manual of Pharmacologic Calculations; With Computer Progra Ronald J. Tallarida,Rodney B. Murray Book 1987Latest edition Springer-Verlag New

Pedagogy

gentle

Dissociation Constant II: Partial Agonists,A partial agonist is an agent that requires appreciable receptor occupancy in order to achieve an effect. By way of contrast, full agonists (or strong agonists) have a large spare receptor capacity, that is, these agents produce effects with just a small fraction of their receptors occupied.

grounded

Linear Regression I,that “best fits” a set of data points (., .), = 1,…, .. The usual criterion for defining the best fitting straight line is that the sum of the squares of the vertical deviations from the observed point to the corresponding point on the line is a minimum—a least squares method.

Jingoism

考博

Analysis I: Schild Plot,concentration of the antagonist is used along with graded concentrations of an agonist acting on the same receptor. The presence of the antagonist shifts the agonist dose—response curve to the right as seen in Figure 15.1.

Enervate

粗野

,Enzyme Kinetics I: Michaelis—Menten Equation,The rate of disappearance of the substrate, denoted by ., is proportional to the concentration of substrate up to a certain substrate concentration. With increasing substrate concentrations, a plateau is reached as the enzyme becomes saturated; at this point the maximum velocity . is reached.

conference

occult

parallelism

,Graded dose—response,ne so determined might be used in the comparison of potency (Procedure 10) or in the analysis of the action of a competitive antagonist (Procedure 15). In each of these applications the regression lines are made parallel, and equieffective doses are determined.