Titlebook: Manual of Clinical Oncology; C. D. Sherman (Chairman),K. C. Calman,B. Salvadori Book 19874th edition Springer-Verlag Berlin Heidelberg 198

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Introduction and Surveyshed cancer, usually (in over 50% of cases) progressing fairly rapidly to a terminal situation. With new knowledge, clinical oncologists will need to have a much broader and more comprehensive view of cancer as an extremely long-term process usually lasting many years (see Table 1). In particular, c

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Preventionthat 70%-80% of cancers are caused by environmental factors (although based on an individual genetic make-up that allows the development of cancer), and it is generally agreed that there are usually initiators and promoters of the cancer process giving us opportunities for prevention at both stages.

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Pathologyl demands of the organ involved. Numerous varieties arise from all types of human tissues and the resulting tumours show marked variations in their biological behaviour. It is thus difficult to devise a simple definition of tumours that will be appropriate for all.

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Evaluation of the Extent of Diseasechapter, is essential before therapeutic decisions (discussed in the next chapter) are made. Radical treatment designed for cure (particularly surgical treatment) is usually not indicated if there is spread of the cancer beyond the limits of the proposed treatment field. Even when using chemotherapy

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Principles of Treatmentr surgery and responsiveness to ionising radiation, chemical agents and hormones. This variability of features, characterising diseases traditionally designated by a common term, and the variability of methods used for their diagnosis and treatment call for a collective approach to all problems conn

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