Titlebook: Management of Infections in the Immunocompromised Host; Brahm H.‘Segal Book 2018 Springer International Publishing AG, part of Springer Na

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Role of Deficits in Pathogen Recognition Receptors in Infection Susceptibility, have also been reported. In this chapter, we discuss the contribution of host genetic variation in pattern recognition receptors to susceptibility to infectious disease. By deciphering the molecular and cellular processes that regulate human susceptibility to infection, this knowledge is predicted

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T Cell Defects,lymphoproliferation, inflammation, and autoimmunity, notably inflammatory bowel disease. The relatively poor prognosis of T cell immune deficiencies requires those affected to initiate extensive antimicrobial prophylaxis often combined with immunosuppressive treatments to control inflammatory compli

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Infections in Hematopoietic Stem Cell Transplant Recipients, cord blood stem cells, or haploidentical donors. In addition to immunosuppressive therapy, in vitro or in vivo manipulation of the graft to prevent GvHD may lead to a greater risk of infections. Although HSCT is associated with profound immune defects, appropriate prophylactic and treatment strateg

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Role of Immunoglobulin Therapy to Prevent and Treat Infections,e current anti-infective armamentarium, approaches that target the host through manipulations to augment the host immune response provide a helpful aid to conventional treatment options. A substantial body of evidence has demonstrated that strategies aiming to support or stimulate immune response co

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