Titlebook: Management of Bone Disease and Kidney Failure in Multiple Myeloma; A Pocket Guide Elena Zamagni Book 2021 Springer Nature Switzerland AG 20

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Leo Rasche,Anke Heidemeier,Stefan Delorme,Niels Weinholdelchem Kontext der Begriff verwendet wird, und insbesondere, aus welchem Grund und mit welchem Ziel Coaching in Anspruch genommen wird. Entscheidend ist dabei auch die theoretische Ausrichtung, die dem gew?hlten Ansatz zugrunde liegt. Gerade für den Umgang mit den aktuellen Herausforderungen hat sic

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Introduction: Management of Bone Disease and Kidney Failure in Multiple Myeloma,noclonal immunoglobulin (M component, MC) in the bone marrow (BM) or, more rarely, in extramedullary tissues. Clinical signs and symptoms at the onset of MM are varied and typically related to the expansion of the neoplastic mass and/or the production by neoplastic cells of cytokines or other factor

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The Pathophysiology of Myeloma Bone Disease: Bone Remodelling and the Role of Osteoclasts,he vast majority, this is irreversible and significantly adds to the already heavy disease burden. Over the last decade, the pathophysiology and complexity of bone destruction in myeloma have become increasingly evident, here we explore the multiple normal physiological pathways and cell types that

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The Pathophysiology of Myeloma Bone Disease: Role of Osteoblasts and Osteocytes,ll infiltration that induces an increased osteoclast (OCL) recruitment and activity, together with the suppression of bone formation. The hallmark of osteolytic lesions in MM is the lack of bone healing due to the suppression of the bone formation process..Osteoblast (OB) formation is impaired by th

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Imaging Techniques for Response Assessment and Follow-Up,ent at the iliac crest. This type of heterogeneity can potentially lead to spatial differences in response to anti-MM therapy, highlighting the issue that bone marrow (BM) specimens from a single site are not always representative for the entire BM cavity. Medical imaging could be the key to overcom

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New Perspectives in Imaging Techniques,(PET) imaging tracers are needed to overcome limitations of .fluoro-deoxyglucose (FDG), in order to improve tumor characterization by targeting other metabolic pathways or biomarkers expressed by neoplasm’s cells. .C-Methionine, which uptake reflects the increased protein synthesis of malignant cell

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Therapy of Myeloma Bone Disease,evelopment of myeloma-related bone disease. Along with other factors, they participate in increased osteoclast activity, decreased osteoblast function, and immunosuppressed marrow microenvironment that deregulate bone turnover and result in bone loss and skeletal-related events. Bisphosphonates are

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Orthopaedic Management in Multiple Myeloma: What Is the Role and When?,all with pathological fracture or via the fracture clinic following episodes of pain or functional loss. It is therefore imperative that both haematologists and orthopaedic surgeons have an appreciation the diagnostic principles related to the management of skeletal-related events, in order to offer

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