Titlebook: Mammalian Transient Receptor Potential (TRP) Cation Channels; Volume II Bernd Nilius,Veit Flockerzi Book 2014 Springer International Publis

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The TRPCs–STIM1–Orai Interaction membrane, the store-operated Ca. channels (SOCs). The two known SOCs are the Orai and TRPC channels. The SOC-dependent Ca. influx mediates and sustains virtually all Ca.-dependent regulatory functions. The signal that transmits the Ca. content of the ER stores to the plasma membrane is the ER resid

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The TRPC Family of TRP Channels: Roles Inferred (Mostly) from Knockout Mice and Relationship to ORAIy excitable or non-excitable, Ca. enters through channels that are activated downstream of phosphoinositide mobilization (activation of phospholipase C, PLC) and through channels that are activated secondary to depletion of internal stores. Depletion of internal stores activates plasma membrane chan

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