Titlebook: Male Hypogonadism; Basic, Clinical and Stephen J. Winters,Ilpo T. Huhtaniemi Book 2017Latest edition The Editor(s) (if applicable) and The

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Exercise and Male Hypogonadism: Testosterone, the Hypothalamic-Pituitary-Testicular Axis, and Exerc exercise training, testosterone will acutely increase, decrease or have no change in concentration, depending on many factors including exercise modality, intensity, and duration. Exercise training places a tremendous amount of stress on the body, and if excessive or not managed appropriately, it c

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Environmental Causes of Testicular Dysfunction, (smoking, alcohol, sedentation, recreational drugs, pharmaceutical drugs) or chemical exposures (e.g., pesticides and other endocrine-disrupting compounds). Such factors may cause their impact via effects during fetal development (i.e., maternal pregnancy effects) or in adulthood, or via a combinat

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Sex Hormone-Binding Globulin and the Metabolic Syndrome,phic balance between circulating testosterone and estradiol levels. In men, low testosterone levels are a major risk factor for the MetS, and testosterone replacement therapy has been proposed as treatment option for associated conditions, i.e., type 2 diabetes and cardiovascular disease. The plasma

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An Ensemble Perspective of Aging-Related Hypoandrogenemia in Men,y weight, nutrition, and the presence of diabetes mellitus. The 0.8–1.3% annual fall in nonSHBG bound “bioavailable” testosterone levels results in a reduction of 30–50% by the sixth to eighth decades of life. Low testosterone concentrations are associated with relative sarcopenia, osteopenia, visce

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Obesity and Aging in Late-Onset Hypogonadism,pituitary function which are aggravated by changes due to aging-related chronic illnesses. Obesity, independent of age, is also associated with low T from low SHBG and down-regulation of hypothalamic–pituitary gonadotropin secretion, the mechanisms for which may involve adipokines, pro-inflammatory

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Androgen Therapy for Hypogonadism in Men with Chronic Illnesses,gy, and poor sleep in conjunction with observable sarcopenia and osteopenia, are prominent in many of these chronic disorders, and are reminiscent of symptomatic hypogonadism. Unequivocally androgen-responsive organs include bone, striated muscle, cardiac muscle, vascular smooth muscle, brain and ad

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