Titlebook: Macrophages: Biology and Role in the Pathology of Diseases; Subhra K. Biswas,Alberto Mantovani Book 2014 Springer Science+Business Media N

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Alternative Activation of Macrophages: Concepts and Prospectsll as adaptive immunity to infection, mediating trophic as well as injurious interactions with their local and systemic environment. The concept of macrophage activation has evolved over recent decades, from relatively simple paradigms to bewildering complexity. This chapter will review the backgrou

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The Antimicrobial Functions of Macrophagescess whereby macrophages engulf microbial prey is termed phagocytosis and it is central to their immunity-related functions. Through phagocytosis macrophages destroy microbial invaders and subsequently display at their cell surface prey-derived antigens to educe adaptive immunity. To further shape i

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Vascular Modulatory Functions of Macrophagesrocesses. Historically, the ability of macrophages to promote vascular growth has been primarily attributed to their secretion of proangiogenic growth factors, like VEGFA, and matrix-remodeling enzymes, like metallo-proteinases. Recent studies have also suggested that physical contacts with endothel

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Airway Macrophages: Sentinels of Healthsurface is also exposed to a myriad of environmental factors, some of which may be pathogenic. Inflammation in the lung impedes its primary function and for this reason a specialised environment exists that prevents innate immune cell activation unless the threat is significant. Airway macrophage ar

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Microglial Ontogeny and Functions in Shaping Brain Circuitsglia are not only the first immune sentinels of infection and inflammation, but are also involved in the maintenance of brain homeostasis. Emerging data are showing new and fundamental roles for microglia in the control of neuronal proliferation and differentiation, as well as in the formation of sy

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