Titlebook: Macrophage Biology and Activation; Stephen W. Russell (Wilkinson Distinguished Profes Book 1992 The Editor(s) (if applicable) and The Auth

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,Chronic Granulomatous Disease: An Update and a Paradigm for the Use of Interferon-γ as Adjunct Immute superoxide and related oxygen intermediates renders the patients with this disease susceptible to recurrent bacterial and fungal infections. The clinical syndrome (reviewed . et al. 1988) usually presents within the first years of life with a history of recurrent infections, mostly pneumonias, ab

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Stephen W. Russell (Wilkinson Distinguished Profes

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Urokinase-Catalyzed Plasminogen Activation at the Monocyte/Macrophage Cell Surface: A Localized andproduce PAs, and the regulation of their PA-dependent proteolytic activity has been a focus of attention in recent years. The findings of a number of investigators converge to suggest that the expression of PA activity is a tightly controlled phenotypic property of human and murine mononuclear phago

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Macrophage-Derived Growth Factors,s in the 1970s and early 1980s. The production of transformed foci of cells by introduction of fragments of cloned transcripts or genes from tumors also produced a subclass of oncogenes that turned out to be growth factors [c-., or PDGF-B chain, and Kaposi’s sarcoma-fibroblast growth factor (kFGF, o

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Mononuclear Phagocytes as Targets, Tissue Reservoirs, and Immunoregulatory Cells in Human Immunodefrtually all infected blood leukocytes throughout HIV disease are CD4. T cells (. et al. 1989; . et al. 1989). Indeed, in late-stage disease about 1 in 40 CD4. T cells harbor virus. Attempts to detect viral protein or mRNA in blood leukocytes of seropositive patients, however, reveal a frequency of p

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older Volume 27 contains literature published in 1980 and received before August literature which was received late and which is not recorded in earlier volumes is also included. We acknowledge with thanks contributions to this volume by Dr. J. Bouska, Prague, who surveyed journals and publications

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S. Gordon,L. Lawson,S. Rabinowitz,P. R. Crocker,L. Morris,V. H. Perry