Titlebook: Macromolecular Protein Complexes IV; Structure and Functi J. Robin Harris,Jon Marles-Wright Book 2022 The Editor(s) (if applicable) and The

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Book 2022d macromolecular foundations established by previous volumes of the .Subcellular Biochemistry. series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established. .The 17 interesting chapters included in this book have been organised into

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The Fork Protection Complex: A Regulatory Hub at the Head of the Replisome,egulate fork progression. Other flexibly linked domains and motifs mediate interactions with proteins and specific DNA structures, enabling the FPC to act as a hub at the head of the replication fork.

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The Conformational Dynamics of Heterotrimeric G Proteins During GPCR-Mediated Activationring receptor-mediated G protein activation and GPCR-G protein coupling selectivity is only now emerging. This review discusses recent studies on the dynamic conformational changes of G proteins and provides insight into the structural mechanism of GPCR-mediated G protein activation.

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Structure of Motile Cilia closely related to the motility mechanism, such as ciliogenesis, cilia-related diseases, and sensory cilia. Subnanometer-scale to submillimeter-scale 3D imaging of the axoneme and the basal body resulted in a wide variety of insights into these questions.

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Structure and Dynamics of the Human Multi-tRNA Synthetase Complex,ogical processes including protein synthesis is still unclear, maintaining the structural integrity of MSC is essential for life. This chapter deals with current knowledge on the structural aspects of the human MSC and its protein components. The main focus is on the regulatory functions of MSC beyond its catalytic activity.

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Fatty Acid Synthase: Structure, Function, and Regulation, cell, and precursors to second messenger molecules. In keeping with its central metabolic role, FA biosynthesis impacts several cellular functions and its misfunction is linked to disease, such as cancer, obesity, and non-alcoholic fatty liver disease. Cellular FA biosynthesis is conducted by fatty

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ATP-Binding Cassette Transporters: Snap-on Complexes?,e structure of these transporters and many reviews have been written on that subject. In contrast, less has been written on the assembly of ABC transporter complexes and this will be a major focus of this book chapter. The complexes are formed from two cytoplasmic subunits that are highly conserved