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Titlebook: Macrolide Antibiotics; Wolfgang Sch?nfeld,Herbert A. Kirst Book 2002 Springer Basel AG 2002 Antibiotika.Infektionskrankheiten.Sexually Tra

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書目名稱Macrolide Antibiotics
編輯Wolfgang Sch?nfeld,Herbert A. Kirst
視頻videohttp://file.papertrans.cn/622/621038/621038.mp4
叢書名稱Milestones in Drug Therapy
圖書封面Titlebook: Macrolide Antibiotics;  Wolfgang Sch?nfeld,Herbert A. Kirst Book 2002 Springer Basel AG 2002 Antibiotika.Infektionskrankheiten.Sexually Tra
描述There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin is a very complex fermentation product obtained from the soil bacterium Saccharopolyspora ery- thraea (originally named Streptomyces erythreus). The success of erythromycin, based on its efficacy and tolerability, stimulated researchers throughout the world to undertake intense efforts to understand the biology and chemistry of macrolides and to use this experience to improve the properties of this compound class. The second generation of macrolides, based on chemical modifications of erythromy- cin, is currently being in broad use, especially for treatment of respiratory tract infections. We presently foresee the introduction of a new generation of macro- lides, i. e. the ketolides, which have the potential to overcome rising resistance problems. This monograph is intended to give the interested reader an overview on "macrolide experience", covering important areas from basic research to
出版日期Book 2002
關鍵詞Antibiotika; Infektionskrankheiten; Sexually Transmitted Diseases; antibiotics; asthma; bacteria; bacteria
版次1
doihttps://doi.org/10.1007/978-3-0348-8105-0
isbn_softcover978-3-0348-9438-8
isbn_ebook978-3-0348-8105-0Series ISSN 2296-6056 Series E-ISSN 2296-6064
issn_series 2296-6056
copyrightSpringer Basel AG 2002
The information of publication is updating

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Cellular accumulation of macrolide antibiotics. Intracellular bioactivity,ch some molecules are mainly antibacterial (true macrolides) whereas others possess mainly immunosuppressant activity (FK 506, rapamycin) or antifungal activity with host cell inhibitory properties (bafilomycins, concannamycins). Traditional macrolide antibiotics are characterized by a 12- to 16-mem
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Ketolides: novel antibacterial agents designed to overcome resistance to erythromycin A within gramnaseproducing resistant strains appeared in London hospitals very shortly after the early clinical use of penicillin G, and they soon spread worldwide [.]. Erythromycin use rapidly was limited by the development of other drugs active on penicillin G-resistant S. aureus isolates and by the fact that
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Biosynthesis of the macrolide antibiotic, tylosin,rporation studies and bioconversion analysis, with heavy reliance on the use of mutants of . blocked in tylosin production [.-.]. The primary product of the Ty1G polyketide synthase is a 16-atom lactone (protylonolide, synonym tylactone) that subsequently acquires three deoxyhexose substituents (D-m
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