Titlebook: Macmillan Dictionary of Physics; M. P. Lord Textbook 1986Latest edition Palgrave Macmillan, a division of Macmillan Publishers Limited 198

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anagement of advanced malignancies. Nevertheless, obtaining serial samples of metastatic tissue is impractical and complicated by spatial heterogeneity, sampling bias, and invasive procedures. An attractive alternative to overcome these limitations is represented by the analysis of peripheral blood

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M. P. Lordechniquesas well as size exclusion chromatography are employed for the purpose.Also the multiple detection methods each sensitive to a specificmolecular characteristic can provide additional information. Variousdetection methods developed recently such as FT-IR, FT-NMR, andmass spectrometry brought

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M. P. Lordraphy (HPLC) probably represents the most versatile and easily adaptable analytical technique for drug metabolite screening (.). HPLC may therefore now be the method of choice during phase I clinical trials of antineoplastic drugs. For example, within a single week we developed an HPLC assay—using a

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M. P. Lordrins into two broad groups, uroporphyrins (octacarboxylic) and coproporphyrins (tetracarboxylic). However, intermediate carboxylated porphyrin containing 2, 3, 5, 6, and 7 carboxyl groups are now known to exist in normal and pathlogical excreta, which were not differentiated, but which were included

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M. P. Lordith the birth some years ago of the categoric imperative for the reduction of costs in the medical sector. That is, each new technology introduced for health maintenance should demonstrate at least a stabilizing impact on total medical expenditures. Therefore, after reviewing the presently available

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M. P. Lordn) and low levels of the chemicals of interest that must be first separated from each other prior to actual analyte determination. Other occasions where the use of HPLC cleanup occurs is in the analysis of samples containing low levels of analytes in which the HPLC mode of detection is inferior to s