Titlebook: MIF Family Cytokines in Innate Immunity and Homeostasis; Richard Bucala,Jürgen Bernhagen Book 2017 Springer International Publishing AG 20

triptans

悠然

MIF- and CD74-Dependent Mechanisms,migration inhibitory factor (MIF). Studies from recent years demonstrate an important role for CD74 in maintenance of innate and adaptive immune cells. This chapter discusses the MIF/CD74-dependent role in regulating cell survival, metabolism, adhesion, and response to hypoxia in health and disease.

完成才能戰(zhàn)勝

HSP90-Stabilized MIF in Oncogenesis and Cell Growth Control,tion inhibitory factor (MIF) promotes the majority of these hallmarks such as sustaining proliferative signals, evading growth repressors, resisting apoptosis, activating invasion, inducing angiogenesis, and evading immune surveillance. As pro-inflammatory cytokine, MIF also promotes tumor-promoting

Arthr-

CD74, MIF and Breast Tumorigenesis: Insights from Recent Large-Scale Tumour Genomics and Proteomics for many years, and, with the advent of postgenomic tools such as next-generation DNA and RNA sequencing, and mass spectrometry-driven protein profiling, the underlying mechanisms can be studied in a systematic and quantitative way. This chapter discusses recent studies by our group that have shown

HOWL

MIF-Dependent Regulation of Monocyte/Macrophage Polarization,onventional. Unlike other cytokines, MIF is not tightly regulated at the expression level, has a well-conserved nonphysiologic keto-enol tautomerase enzymatic activity, lacks a traditional secretory leader sequence, and has, for its primary cell surface receptor, a protein that shuttles MHC class II

搖曳的微光

Advances in Understanding the Role of MIF in the Pathogenesis of Autoimmune Diseases,andom movement of macrophages. It is now known that MIF has pluripotent effects including promoting the expression of proinflammatory cytokines, having chemokine-like functions, and promoting cell migration and recruitment. Moreover, it plays an important role in sustaining immune cell survival by i

nostrum

Role of MIF in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis,of MIF and CD74 in multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE). MIF is produced by a number of cells that are involved in MS pathology, such as monocytes and T cells. MIF effects on MS and EAE have been attributed to disease progression, as it was sho

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neurologist

BRINK

MIF Mediates Pelvic Inflammation and Pain,f MIF from the urothelium and upregulation of MIF receptors in the urothelium. Binding of released MIF to urothelial MIF receptors starts a signaling cascade that promotes bladder inflammation and pain. In addition, recent evidence shows that released MIF is capable of eliciting bladder pain without