Titlebook: METABIOTICS; PRESENT STATE, CHALL Boris A. Shenderov,Alexander V. Sinitsa,Christine Book 2020 Springer Nature Switzerland AG 2020 probioti

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Introduction,iew of a human organism presents it as a superorganism, a dynamic symbiotic community of various prokaryotic and eukaryotic cells (Vakhitov and Sitkin 2014, Shenderov 2008, Shenderov 2014b, Ugolev 1991, Caselli et al. 2011, Dietert and Dietert 2015, Lederberg 2000). The microbial component of this c

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Contemporary Views on Biotechnological Potential of Symbiotic Microorganisms,s existing in nature, including many representatives of anaerobe symbiotic bacteria in the human gut, are difficult and often impossible to cultivate in ordinary microbiological laboratories (Browne et al. 2016). As many as 1000–10,000 prokaryotic microorganism species are present in 1?g of soil. Ou

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The Digestive Function of Human Gut Microbiota,molecular entities amount to over 20 thousand of different macro- and micronutrients (Shenderov 2018). Around 70% of the total microbiota inhabiting the human organism is localized on its digestive tract mucosa. A. M. Ugolev deserves credit for providing convincing evidence of symbiotic microorganis

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Metabolic Relationship Between the Host and Its Gut Microbiota,unds. With regard to potential biological effects, the most extensively studied are short-chain fatty and bile acids, choline metabolites, the derivatives of phenol, benzene and phenyl, indole derivatives, vitamins, polyamines, lipids, enzymes and other proteins, amino acids (Beloborodova et al. 201

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Contemporary Microecological Strategies of Gut Microbiota Modulation for Human Health Preservation,ic and functional foods as well as therapeutics that support alimentary and other functions of gut microbiota. To create or restore the impaired human biocenoses, various targeted microecological techniques and methods are used (Table 1), with a focus on either prevention or treatment. In the longer

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Molecular Language of Symbiotic Gut Microorganisms,ize to bacterial cells or smaller can easily penetrate intestinal mucosa. Owing to contemporary chromatography and mass spectrometry methods, many similar low molecular weight particles and molecules are easily detectable in blood, urine and other human biological fluids. Their appearance in these f

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Drawbacks and Negative Consequences of Traditional Probiotics Based on Live Microorganisms,r sufficient prophylactic and, if less marked, therapeutic effects. However, it is currently impossible to precisely determine the optimum quantity of bacteria required for beneficial probiotic effects on human health; in many cases exact data are lacking on probiotic effect mechanisms and targets.