Titlebook: Lung Cancer and Personalized Medicine; Current Knowledge an Aamir Ahmad,Shirish Gadgeel Book 2016 The Editor(s) (if applicable) and The Aut

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Epidemiology of Lung Cancer,mal regions on 15q25, 6p21 and 5p15 associated with lung cancer risk. Risk prediction models for lung cancer typically include age, sex, cigarette smoking intensity and/or duration, medical history, and occupational exposures, however there is not yet a risk prediction model currently recommended fo

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Immune Therapy,eveloped and studied in lung cancer patients and phase 3 clinical trials are ongoing. Many different immunotherapies have shown promising clinical effects in patients with limited and advanced stage lung cancer, however, future years will have to tell whether immunotherapy will earn its place in the

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Anti-angiogenesis in Personalized Therapy of Lung Cancer,..Multiple oral anti-angiogenic compounds have been evaluated in NSCLC, both in first-line therapy, or upon disease progression. The majority of agents have shown some evidence of activity, but none have clearly demonstrated improvements in overall survival. Increased toxicities have been observed,

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Target Therapy in Lung Cancer,g Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) [3], further increasing the histological heterogeneity and improving the existing WHO-classification. Is now the beginning of personalized therapy era that is ideally finalized to treat each individual case of

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Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors and Therapeutic Approaches: An Update,h to overcome TKI resistance is to potentiate EGFR protein for degradation. These studies will best be utilized when we can identify the oncogene addictions in an individual patient and tailor the therapy/therapies accordingly for the maximum benefits.

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Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer,y more questions that remained to be answered in the future. This book chapter will provide a concise summary of the importance of ALK signaling pathway in lung cancer. Understanding the ALK signaling pathway in lung cancer will likely provide the roadmap to the management of major epithelial malign

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0065-2598 rent research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies..978-3-319-79592-8978-3-319-24223-1Series ISSN 0065-2598 Series E-ISSN 2214-8019