Titlebook: Longevity Genes; A Blueprint for Agin Gil Atzmon, PhD Book 2015 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Autophagy and Aging,autophagy pathways—macroautophagy and chaperone-mediated autophagy, and discusses how changes in these pathways associate with age-associated disorders. Understanding how to maintain “clean cells” by activation of autophagy could be an attractive strategy to maintain healthspan in aged individuals.

Flatter

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GWAS and Meta-Analysis in Aging/Longevity,other traits for which GWAS has been successful. One may argue that rare variants explain the high heritability of longevity and the segregation of the trait in families. Yet, whole genome analyses of GWAS data still suggest that over 80?% of the heritability is explained by common variants. Althoug

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Systems Biology of Aging,r characteristics (Somero, Ann Rev Physiol 57:43–68, 1995). Existing theories of aging suggest that damage occurs to the conformations or sequences of molecules, which only shifts focus onto the implied failure of repair mechanisms. Contrarily, heat-induced changes affect the behavioral characterist

persistence

Epigenetics of Aging, expectancy has increased steadily over the last two centuries [.], however, a significant proportion of the extra life years is associated with many types of morbidity. Age-related diseases, including cancer, cardiovascular diseases and dementia, are now the dominant health problems among the elder

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Book 2015. It?touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes?the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate

climax

David Karasik Ph.D.,Anne Newmanzuf?llige Zusammentreffen von derartigen Faktoren mit einer erh?hten Erkrankungsrate der Koronararterien, der Gef??e des Gehirnkreislaufs oder mit peripheren Zirkulationsst?rungen führte dazu, diese Ger??e als Risikoindikatoren, bzw. Risikofaktoren, für die Entstehung einer Arteriosklerose zu bezeic