Titlebook: Local Immunosuppression of Organ Transplants; Scott A. Gruber Book 1996 Springer-Verlag Berlin Heidelberg 1996 drug.drug delivery.drug dev

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Selective Immunosuppression by Local Treatment of the Allograft increased concerning the role of systemic versus local regulatory mechanisms in the cellular immune response.. Immune stimulation by major histocompatibility complex (MHC) antigen expression has been seen as a local as well as a systemic process in both allograft rejection and autoimmune disease..

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Local Immunosuppression of Rat Cardiac, Liver, and Small Bowel Allograftsc administration of immunosuppressive agents prevents graft rejection, toxic side effects cause the dysfunction of vital organs including kidney, liver and bone marrow.. In addition, current immunosuppression is associated with an increased incidence of infection, diabetes, hypertension and malignan

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Intraportal Delivery of Immunosuppressants to Intrahepatic Islet Allograftsas recognized by the host through peripheral sensitization. Host immune cells circulating through the graft were exposed to nonself histocompatibility antigens. Subsequent proliferation of responder cells occurred in the spleen or lymph nodes. The effector response was mediated by sensitized lymphoi

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Local Heparin, 6-Mercaptopurine, Prednisolone, and Mizoribine Delivery in a Canine Renal Allograft Mwhen one considers the potential for eventual clinical application. The osmotic pumps utilized for drug delivery are inaccessible within the abdomen, cannot be emptied of and refilled with drug, and can only infuse drug for a 2 week interval. As a result, long-term considerations such as pump compat

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