Titlebook: Liver Immunology; Principles and Pract M. Eric Gershwin,John M. Vierling,Michael P. Manns Book 2020Latest edition Springer Nature Switzerla

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Adaptive Immunity and the Clinical Definition of Autoantibodies,ific for autoimmune hepatitis. Anti-mitochondrial antibody is the serological hallmark of primary biliary cholangitis and has high disease specificity. Rim-like and multiple nuclear dots anti-nuclear antibodies are also specific for primary biliary cholangitis and are of particular diagnostic value

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The Microbiota-Gut-Liver Axis: Implications for the Pathophysiology of Liver Disease,ework, disrupted microbiota and their products gain access to the gut-associated immune system via a permeable gut barrier and generate inflammatory responses. Disruption of the gut vascular barrier then permits access for bacterial components as well as pro-inflammatory cytokines to the portal circ

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Diagnostic Liver Immunology,oantibodies are key to the diagnosis of primary biliary cholangitis and autoimmune hepatitis: the first is characterized by positive anti-mitochondrial antibody and/or anti-nuclear antibody giving the nuclear membrane or the multiple nuclear dots pattern on HEp2 cells, whereas the latter is characte