Titlebook: Leukotrienes; New Concepts and Tar Ian Rodger,Jack Botting,Sven-Erik Dahlén Book 1998 Springer Science+Business Media Dordrecht 1998 asthma

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Enzymes involved in the production of leukotrienes and related molecules,sponses.. In particular, LTs have been implicated in the pathology of human bronchial asthma., and two .. receptor antagonists (montelukast and zafirlukast) and one 5-lipoxygenase (5-LO) inhibitor (zileuton) have been approved for the treatment of human bronchial asthma in several countries outside

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Cysteinyl-leukotriene receptors and transduction mechanisms in airway cells,, basophils and mast cells. are able to synthesize cys-LTs from arachidonic acid but cys-LTs can also be produced through transcellular metabolism from neutrophil-derived LTA., by vascular endothelial cells. and platelets..

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How to measure leukotrienes in man,events in the airways as part of an asthmatic attack.. There is still a debate in the literature whether the proinflammatory compound LTB., formed from the common unstable epoxide intermediate LTA., also contributes to the airway inflammation associated with asthma..

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Influence of leukotrienes and anti-leukotrienes on airway tone and migration of inflammatory cells,LAP) to generate the unstable epoxide LTA. which is then either converted to LTB., or via LTC. synthase to the cysteinyl leukotriene (cys-LT) LTC.. LTC. is converted by y-glutamyltranspeptidase to LTD. and by a dipeptidase to LTE.. The cysteinyl leukotrienes, LTC., LTD. and LTE., comprise the activi

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Leukotrienes in airways obstruction and inflammation evoked by allergen,hat immunological challenge of guinea-pig lung resulted in the reìease of similar SRSs.. Since then the investigation of allergen challenge of sensitized tissues or whole animals has been central to the study of SRS-A and leukotrienes (LTs). Early studies into the biological actions of SRS-A suggest

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Leukotrienes in induced airway obstruction,esult of a balance of contractile cysteinyl-leukotrienes (cys-LTs), and, to a lesser extent, histamine. and bronchodilator prostanoids, such as prostaglandin E.. While the source of the prostanoid is believed to be airway epithelial cells., histamine and leukotrienes (LTs) are likely to be produced

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