Titlebook: Leukemia and Lymphoma; Detection of Minimal Theodore F. Zipf,Dennis A. Johnston Book 2003 Springer Science+Business Media New York 2003 DNA

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Measurement of Minimal Residual Disease in Children Undergoing Allogeneic Stem Cell Transplant for deemed to be at an unacceptably high risk of relapse after chemotherapy alone. Although indications for ASCT vary between major treatment cooperatives, it is generally considered to be the treatment of choice for a minority of children with ALL in first remission and many of those who suffer a bone

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Investigation of Minimal Residual Disease in Acute Myeloid Leukemia by Immunophenotyping,due to the persistence of low numbers of residual neoplastic cells which are undetectable by conventional morphological techniques (minimal residual disease [MRD]), still occur in most patients; in fact, only around one-third of patients with AML are leukemia-free at 5 yr. Owing to this, patients ar

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Real-Time Polymerase Chain Reaction of Genomic DNA for Quantitation of t(14;18),he detection of viral nucleic acid sequences. Quantitative PCR can be performed by measuring the product either after a given number of cycles (end-point quantitative PCR), which requires the generation and quantification of an internal standard for each tube. Alternatively, quantitation can be acco

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,Editors’ Notes,as the result of developments in laser technology, fluorochrome chemistry, optical hardware, and data analysis software. These advances, accompanied by technical advice, are presented in the excellent review article of Baumgarth and Roederer ..