Titlebook: Laser/Optoelektronik in der Technik / Laser/Optoelectronics in Engineering; Vortr?ge des 8. Inte Wilhelm Waidelich (o. Professor, Vorstand,

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P. Klopotek,U. Brinkmann,P. Oesterlin,W. Mückenheimughput cell viability screening to address the issues encountered in the classical strategy using a single fitness indicator described above. The method combines a biochemical, luminescence-based approach and two fluorescence-based assay types. The biochemical method assesses cellular fitness by qua

homocysteine

H.-J. Cirkel,R. Baumgartl,W. Bette,D. Friede,R. Müller Using a quantitative high-throughput screening (qHTS) approach, we are able to screen large chemical libraries to profile potential small molecule modulators of the HIF-1 signaling pathway in a 1536-well format. This chapter describes two orthogonal cell based assays; one utilizing a β-lactamase re

achlorhydria

E. Müller-Horsche,D. Basting,U. Brinkmann,P. Oesterlin,W. Mükenheim Using a quantitative high-throughput screening (qHTS) approach, we are able to screen large chemical libraries to profile potential small molecule modulators of the HIF-1 signaling pathway in a 1536-well format. This chapter describes two orthogonal cell based assays; one utilizing a β-lactamase re

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SOBER

Gary K. Klauminzerafish, with its well-documented advantages over many animal models, is now emerging as a true biosensor of chemical activity. Herein, we draw on nearly a decade of experience developing high-throughput toxicology screens in the developmental zebrafish to summarize the best practices in fulfilling th

猜忌

P. Chall,D. van Eck,H. v.d. Pas,F. Kuijpersn. is a valuable resource for scientists pursuing chemical toxicology research. This book will aid scientists and researchers in translating new HTS techniques into standardized chemical toxicology assessment tools that can refine, reduce, and replace animal testing.?.978-1-0716-2215-5978-1-0716-2213-1Series ISSN 1064-3745 Series E-ISSN 1940-6029

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瘋狂

H. P. Kortzser-friendly format suitable for modeling and other informatics analysis (e.g., gathering PubChem data for hundreds or thousands of chemicals in a modeling friendly format) directly through the PubChem web portal is not feasible. This chapter aims to introduce two approaches to obtain the HTS assay