Titlebook: LC-MS in Drug Bioanalysis; Q. Alan Xu,Timothy L. Madden Book 2012 Springer Science+Business Media, LLC 2012 Bioanalysis.LC-MS.LC-MS/MS.Liq

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Pitfalls of LC-MS/MS in the Clinical Laboratory,nical laboratories worldwide. It found its sound place amongst major basic routine technologies of laboratory medicine as enzyme based assays or immunoassays. LC-MS/MS extended the technological armamentarium of clinical laboratories significantly, both in analytical and economical terms. Especially

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Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics,herapeutic drug monitoring is well accepted and widely practiced for many drugs and is also relevant for drugs for which pharmacogenomic testing is needed. Tamoxefin is metabolized by CYP 2D6 to endoxifen, clopidogrel by CYP 2C19 to thiol-containing active metabolite, and opioid drugs by 2D6 to morp

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Liquid Chromatography-Mass Spectrometry for the Determination of Antidepressants and Some of their for identification and quantification of these therapeutic drugs should be available in clinical and toxicological laboratories. Improvements in liquid chromatography-mass spectrometry LC-MS(MS) technology over the last two decades have favored this technique to be one of the most commonly employed

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Therapeutic Drug Monitoring of Targeted Anticancer Therapy. Tyrosine Kinase Inhibitors and Selectivapy to chronic oral treatment with targeted molecular therapies. Most oral anticancer-targeted drugs approved at present are tyrosine kinase inhibitors (TKIs) and some of them are accompanied with diagnostic test aiming at preselecting patients who are more likely to respond to anticancer treatment,

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Applications of Mass Spectrometry in Analyses of Steroid Hormones,teroid hormones as biomarkers in endocrinology and pathology diagnoses, doping drugs in athletes and racing horses, residuals in food safety concerns, and environmental pollutants in water and sediments. Both liquid chromatography mass spectrometry (LC-MS or LC-MS/MS) and gas chromatography mass spe

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Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techninthetic drugs, most of them (e.g. atropine, benzatropine, .-butyl scopolamine, cimetropium, homatropine, ipratropium, .-methyl scopolamine, scopolamine, tiotropium, trospium) antagonizing acetylcholine at muscarinic receptors (MR) and some of them (e.g. bemesetron, granisetron, scopolamine, tropiset

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Analysis of Illicit Drugs in Human Biological Samples by LC-MS,,tical strategy depending on the aim of the analysis and/or on the availability of the sample or on which kind of information is needed. Liquid chromatography–mass spectrometry (LC-MS or LC-MS/MS) has provided a helpful tool in this field especially for hydrophilic, thermolabile, and nonvolatile anal

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