Titlebook: L-Arginine in Clinical Nutrition; Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendra Book 2017 The Editor(s) (if applicable) and The Autho

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Regulation of Expression and Activity of ,-Arginine Transporters by Nutrients and Hormones: A Focus ion. Evidence shows that changes in the extracellular environment regulate the expression and activity of .-arginine transporters in order to maintain amino acid uptake, especially for the fine-tuning of NO bioavailability. In other words, the regulation of .-arginine transporters could be a key fac

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-Arginine, Pancreatic Beta Cell Function, and Diabetes: Mechanisms of Stimulated Insulin Release aneducing beta cell secretory function and proliferation following chronic exposure. The effect of reducing .-arginine concentration in vivo may have profoundly negative effects on the beta cell as discussed in this chapter. In addition, pigment epithelium-derived factor (PEDF) may be considered as a

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Erythrocytes By-Products of ,-Arginine Catabolismhesis of arginine uses citrulline as a precursor which, in turn, can be supplied from intestinal glutamine metabolism (Saitoh et al. J Toxicol Sci 39:41–50, 2014). Besides dietary intake, several factors affect the bioavailability of dietary arginine, such as the levels of lysine, manganese, n-3 fat

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-Arginine and Macrophages: Role in Classical and Alternative Activationde tissues, monocytes differentiate and become macrophages. In addition to eliminating pathogens, macrophages also perform other functions. They contribute to the clearance of dust and allergens in lungs (alveolar macrophages) and clear toxins from the liver (Kupffer cells) and senescent red blood c

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Protein ,-Arginine Methylation of RNA-Binding Proteins and Their Impact on Human Diseasesd the functional ability of an RBP. This modular architecture provides versatility: RBP binding with high affinity and specificity to a specific target can be achieved by combining different RBDs that individually recognize shorter RNA sequences with weak affinity. Many RBPs contain additional post-

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DNA–,-Arginine Adducts and Implications in Diseasedy production. Lysine- and arginine-rich histones in nucleosomes on modification by environmental agents form histone–DNA adducts, making it immunogenic. Alteration of DNA resulting from photomodification could lead to the development of antibodies or mutations to modified DNA. Therefore, the DNA–ar

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