Titlebook: Klinische Untersuchungstests in Orthop?die und Unfallchirurgie; Franz Josef Müller,Christian Schuster,Bernhard Wei Book 2013 Springer-Verl

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Franz Josef Müller,Christian Schuster,Bernhard Weigelue in predicting its carcinogenic potential. For new pharmaceuticals, test data from a standard test battery are required prior to administering the compound to humans. This test battery includes in vivo studies of chromosomal damage in the rodent hematopoietic system, traditionally performed in the

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Franz Josef Müller,Christian Schuster,Bernhard Weigelmedia, or metabolic activation. These result in volatile, sorptive, and biotransformation losses of the test compound, and thus to poorly defined exposure. This has implications for the apparent sensitivity of the assay as well as for establishing a reliable relationship between concentration and re

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Franz Josef Müller,Christian Schuster,Bernhard Weigelhan 80% of human cancers are caused by exposure to chemical agents.. One class of chemicals that could pose a significant human health hazard is the N-nitroso compounds. These compounds are widespread in our environment,. occurring in food preservatives,. milk,. tobacco smoke,. meat-curing mixtures,

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Franz Josef Müller,Christian Schuster,Bernhard Weigelovel antigen receptor). Its antigen-binding site consists of one single domain (vNAR) that is reportedly able to engage a respective antigen with affinities similar to those achieved by conventional antibodies. While vNAR domains offer a reduced size, which is often favorable for applications in a t

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Franz Josef Müller,Christian Schuster,Bernhard Weigele recombinant antibody library approaches is ongoing, the major source of antibody-secreting cells (ASCs) remains to be primary B cells of mostly rodent origin. As fainting viability and secretion rates can lead to false-negative screening results, careful preparation of these cells is an essential