Titlebook: Key Clinical Trials in Erectile Dysfunction; Culley C. Carson Book 2007 Springer-Verlag London 2007 BLADON.Clinical Trials.Sexual Dysfunct

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First Clinical Data on Sildenafil: The Arrival of Oral Pharmacotherapy,This represented the first serious publication indicating the potential utility of sildenafil in the treatment of erectile dysfunction (ED). It represented the arrival of oral therapy for the treatment of ED, offering much hope to patients and physicians alike.

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,Original “Gold Standard” Clinical Trial of Sildenafil in ED,Although a pilot study had indicated that sildenafil could produce an erectile response in patients with erectile dysfunction (ED), the full clinical potential had not been explored. This trial in patients with ED arising from different etiologies unequivocally demonstrated the benefit in patients with mild to severe ED.

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Summary of Clinical Trials of Phentolamine,Although it represents a composite of more than one clinical study, this work helps to define the potential of phentolamine in the management of erectile dysfunction (ED). The use of oral (buccal) phentolamine could represent a viable alternative to phospho diesterase (PDE) inhibitors or for use in sildenafil failures.