Titlebook: Ketamine for Treatment-Resistant Depression; The First Decade of Sanjay J. Mathew,Carlos A. Zarate, Jr. Book 2016 The Editor(s) (if applic

存在主義

The History of Ketamine Use and Its Clinical Indications,d “dissociative anesthesia.” In spite of the potential abuse liability, ketamine remains on the World Health Organization (WHO) Model List of Essential Medicines. It has been approved worldwide as the sole anesthetic agent for certain procedures, for the induction of anesthesia, and as an anesthetic

Cosmopolitan

The Basic and Clinical Pharmacology of Ketamine,mber of studies since 2000. Multiple routes of ketamine administration, each with unique pharmacokinetics, have been investigated in the treatment of depression, including intravenous, intramuscular, intranasal, sublingual, and oral delivery..Ketamine is most commonly administered as (.,.)-ketamine,

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Highbrow

Ketamine and Suicide Risk,sociated with reductions in suicidal thoughts have fueled interest in ketamine as an antisuicidal agent. The initial data on ketamine and suicide are promising but have not reached the level and rigor of the ketamine and depression literature (which itself is not conclusive). Existing evidence sugge

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nocturia

,Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies,ge number of back-translational efforts attempting to employ rodent models to better characterize the antidepressant properties of the drug and to improve our understanding of its underlying mechanisms of antidepressant action. On balance, these preclinical studies have yielded fairly consistent fin

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linear

Ketamine and Electroconvulsive Therapy,iated with ECT. A number of randomised controlled trials and other studies have compared ECT outcomes when ketamine (as sole or adjunctive anaesthetic) or other anaesthetic agents are used. The body of evidence to date suggests that adding ketamine to ECT results in a faster onset of antidepressant

Definitive

Emerging Data for Ketamine in Obsessive-Compulsive, Stress-Related, and Substance Use Disorders,e suggests utility in other disorders, including obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and alcohol/substance use disorders. This chapter reviews the available data and suggests new avenues for research.

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Elizabeth Wolf Fourcade,Kyle A. B. Lapidusndamental as calculus. Calculus explains the external world, and probability theory helps predict a lot of it. In addition, problems in probability theory have an innate appeal, and the answers are often structured and strikingly beautiful. A solid background in probability theory and probability mo