Titlebook: Kaposi Sarcoma Herpesvirus: New Perspectives; Chris Boshoff,Robin A. Weiss Book 2007 The Editor(s) (if applicable) and The Author(s), unde

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The Use of Antiviral Drugs in the Prevention and Treatment of Kaposi Sarcoma, Multicentric Castlemafective, unavailable, or toxic to many affected persons. A growing body of basic science, preclinical, and observational data suggests that antiviral medications may play an important role in the prevention and treatment of KSHV-associated disease.

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The KSHV and Other Human Herpesviral G Protein-Coupled Receptors, mitogenic and angiogenic cytokines that are vital to the biology of KS and other KSHV-driven malignancies. Several other herpesviruses also encode GPCRs, the functions of which are under ongoing investigation. In addition, several human diseases are associated with mutated mammalian GPCRs in germline or somatic cells.

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The Rta/Orf50 Transactivator Proteins of the Gamma-Herpesviridae,mologue of each gammaherpesvirus plays a pivotal role in the initiation of viral lytic gene expression and lytic reactivation from latency. Here we discuss the Rta/Orf50 of KSHV in comparison to the Rta/Orf50s of other gammaherpesviruses in an effort to identify structural motifs, mechanisms of action, and modulating host factors.

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Regulation of KSHV Lytic Gene Expression,regulates the expression of downstream viral genes. We summarize the interactions of RTA with cellular and other viral proteins. We also discuss critical issues that must be addressed in the near future.

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Kaposi Sarcoma Herpesvirus-Encoded Interferon Regulator Factors, important regulatory proteins in the cell, including responses to transforming growth factor β (TGF-β) and the tumor suppressor protein p53. This review examines the expression of the vIRFs during the life cycle of KSHV and the functional consequences of their expression.

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Interactions Between HIV-1 Tat and KSHV,c role in the development of KSHV-associated neoplasms. Comprehensive knowledge of the functions of Tat-1 together with the KSHV genes will contribute to a better understanding of the pathogenesis of virus-associated cancers and the interaction of viruses with their hosts.

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nt of the world’s premiere prize for carbohydrate chemistry, Fraser-Reid was groomed for his role as expert witness in the mentioned lawsuit. Nevertheless, it seems more than his career links Fraser-Reid to the case.978-3-642-43327-6978-3-642-22781-3