Titlebook: Kynurenine and Serotonin Pathways; Progress in Tryptoph Robert Schwarcz,Simon N. Young,Raymond R. Brown Book 1991 The Editor(s) (if applica

Diatribe

Autoradiographic Measurement of the Rate of Serotonin Synthesis in the Rat Brainthe rate of synthesis is estimated from the change in the concentration of a tryptophan metabolite after inhibition of an enzyme (tryptophan hydroxylase, aromatic amino acid decarboxylase (AAAD) or monoamine oxidase) or the inhibition of 5-hydroxyindoleacetic acid transport. These approaches can be

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Ambivalence on the Multiplicity of Mammalian Aromatic L-Amino Acid Decarboxylases widely distributed throughout mammalian tissues, occurring most abundantly in the pineal gland, liver, kidney, adrenal medulla, and striatum. Earlier studies concluded that 3,4-dihydroxyphenylalanine decarboxylase (which catalyzes the decarboxylation of dopa, producing dopamine) and 5-hydroxytrypt

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Regulation of Melatonin Synthesis in the Ovine Pineal Gland melatonin synthesis in the pineal gland and its concentration in the circulation on a circadian basis (Axelrod and Zatz, 1977; Klein et al. 1981). NAT activity in the rat increases 50-100-fold at night, causing increased synthesis of melatonin in the pineal gland and about a 10-fold increase in mel

Intervention

Melatonin Synthesis: Multiplicity of Regulationver, subsequent examination of a variety of tissues indicates melatonin is very likely produced in the retina (Gern et al., 1978), the Harderian glands (Bubenik et al., 1976), the extra-orbital lacrimal glands (Mhatre et al., 1988), portions of the gastrointestinal tract (Vakkuri et al., 1985), and

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Sub-Picogram Determination of Serotonin Using HPLC with Electrochemical Detection for Microdialysis is of microdialysis perfusates. In addition, the cost of the components for this system are roughly an order of magnitude less than the cost of a commercial system. The essential components are a pneumatic displacement fluid pump, narrow bore HPLC column, and battery-powered potentiostat for the electrochemical detection of 5-HT.