| 書目名稱 | JAK-STAT Signalling | | 副標題 | Methods and Protocol | | 編輯 | Sandra E. Nicholson,Nicos A. Nicola | | 視頻video | http://file.papertrans.cn/501/500030/500030.mp4 | | 概述 | Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes supplementary materia | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | .The receptor-associated JAK protein kinases and their substrates, the STAT transcriptional activators, transmit signals following cytokine and growth factor binding to receptors expressed on the cell surface, to result in specific transcriptional and cellular responses.?Over the last two decades, the field has progressed from identification of the individual components through to an understanding of the activation and deactivation mechanisms, and the complex structural detail of the proteins involved. We now know that these pathways are important in many biological processes, including growth and development, hematopoiesis, and the innate and adaptive immune response.?.JAK-STAT Signalling: Methods and Protocols.?provides detailed methodologies for examining many aspects of the pathway. Divided into four sections, topics include JAK and STAT specific approaches, the negative regulators of the pathway (SOCS proteins), and the production and crystallization of JAK and STAT proteins, among others.?Written in the successful?.Methods in Molecular Biology?.?series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-ste | | 出版日期 | Book 2013 | | 關(guān)鍵詞 | JAK protein kinases; SOCS proteins; STAT proteins; STAT transcriptional activators; tyrosine proteins | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-62703-242-1 | | isbn_softcover | 978-1-4939-5979-2 | | isbn_ebook | 978-1-62703-242-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Springer Science + Business Media New York 2013 |
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