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Titlebook: Isolation and Molecular Characterization of Circulating Tumor Cells; Mark Jesus M. Magbanua,John W. Park Book 2017 The Editor(s) (if appli

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發(fā)表于 2025-3-21 18:56:31 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Isolation and Molecular Characterization of Circulating Tumor Cells
編輯Mark Jesus M. Magbanua,John W. Park
視頻videohttp://file.papertrans.cn/476/475756/475756.mp4
概述Informative and authoritative, this book presents state-of-the-art strategies for CTC research from experts and key opinion leaders in the field.This book contains creative and innovative ideas for ra
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Isolation and Molecular Characterization of Circulating Tumor Cells;  Mark Jesus M. Magbanua,John W. Park Book 2017 The Editor(s) (if appli
描述Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technological advancements in rare-cell technology, however, have allowed for the reliable enrichment and isolation of CTCs. Consequently, the use of recently developed molecular approaches —e.g., multiplexed QPCR, microarray, and next generation sequencing analyses— to profile CTCs have provided novel insights into the molecular makeup of these tumor cells. This book discusses approaches for enrichment and isolation of CTCs as well as recent advances in comprehensive molecular profiling of CTCs using cutting-edge omics technology.
出版日期Book 2017
關(guān)鍵詞Circulating tumor cells; Rare-cell technology; Expression profiling; Genomic DNA profiling; Clinical app
版次1
doihttps://doi.org/10.1007/978-3-319-55947-6
isbn_softcover978-3-319-85787-9
isbn_ebook978-3-319-55947-6Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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發(fā)表于 2025-3-21 23:41:30 | 只看該作者
Strategies for Isolation and Molecular Profiling of Circulating Tumor Cells,asis occurs when tumor cells leave the primary tumor, travel through the blood stream as circulating tumor cells (CTCs), and then colonize secondary tumors at sites distant from the primary tumor. The capture, identification, and analysis of CTCs offer both scientific and clinical benefits. On the s
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Enrichment and Detection of Circulating Tumor Cells and Other Rare Cell Populations by Microfluidicge of these strategies is that CTCs with low EPCAM expression will be missed. Isolation by size using filter membranes circumvents the reliance on this cell surface marker, and can facilitate the capture not only of EPCAM-negative CTCs but other rare cells as well. These cells that are trapped on th
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發(fā)表于 2025-3-22 20:18:12 | 只看該作者
Detection and Enumeration of Circulating Tumor Cells with Invasive Phenotype, development; thus, CTC assays are an important clinical tool for monitoring progression and evaluating prognosis in cancer. However, CTCs are limited in number and heterogeneous in their biological and physical properties, making their detection, isolation, and enumeration a major challenge. To ove
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發(fā)表于 2025-3-23 00:44:45 | 只看該作者
Molecular Profiling and Significance of Circulating Tumor Cell Based Genetic Signatures, patients with cancer, however, once metastasis occurs, responses to conventional therapies become significantly less effective, and this remains the leading cause of death. Circulating tumor cells (CTCs) are tumor cells that have preferentially disseminated from the primary tumor mass into the hema
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Detection of Gene Rearrangements in Circulating Tumor Cells: Examples of ,-Rearrangements in Non-Smls is a critical parameter for exploiting CTCs for predictive biomarker’s detection, we developed a FISH (fluorescent . hybridization) method for CTCs enriched on filters (filter-adapted FISH [FA-FISH]) that was optimized for high cell recovery. To increase the feasibility and reliability of the ana
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發(fā)表于 2025-3-23 06:22:59 | 只看該作者
Enrichment, Isolation and Molecular Characterization of EpCAM-Negative Circulating Tumor Cells,and prostate cancer, as well as the prognosis of other tumor types. In addition, recent studies have suggested that the presence of CTCs undergoing epithelial-to-mesenchymal transition and, as such, may exhibit reduced or no expression of epithelial proteins e.g. EpCAM, might be related to disease p
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