Titlebook: Islets of Langerhans; Md. Shahidul Islam Reference work 2015Latest edition Springer Science+Business Media Dordrecht 2015 Beta cells.Diabe

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https://doi.org/10.1007/978-94-007-6686-0Beta cells; Diabetes; Insulin; Islet transplantation; Islets

micronutrients

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Electrophysiology of Islet Cells,. and/or Ca. channels and repolarized by voltage- and/or Ca.-dependent K. channels. At a constant stimulatory glucose concentration, APs are clustered in bursts that are interrupted by hyperpolarized interburst phases. Bursting electrical activity induces parallel fluctuations in [Ca.]. and insulin

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ATP-Sensitive Potassium Channels in Health and Disease,oduce a milder phenotype. Similarly mutations that greatly reduce the ATP sensitivity of the K. channel lead to a severe form of neonatal diabetes with associated neurological complications, while mutations that cause smaller shifts in ATP sensitivity cause neonatal diabetes alone. This chapter revi

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,β Cell Store-Operated Ion Channels,cular mechanisms remain undefined. In this chapter, we provide both an overview of our current understanding of ionic currents regulated by ER Ca. stores in insulin-secreting cells and a review of studies in other cell systems that have identified the molecular basis and regulation of SOCE.