Titlebook: Ir Genes; Past, Present, and F Carl W. Pierce,Susan E. Cullen,Donald C. Shreffler Book 1983 The HUMANA Press Inc. 1983 Antigen.DNA.Macropha

寬度

Ia Genes, Gene Products, and Determinantsggested that duplicated A., A., E. and E. genes may exist. Each of them would carry some common Ia determinants and some unique Ia determinants identified by monoclonal antibodies. Random association of the polypeptide chains could generate multiple Ia molecules, and numerous combinatorial determina

護身符

Antibody and T Cell Recognition of Select Ia Determinants Using the I-A Mutant B6.C-,,es between bm12 and B6 mice. This approach not only allows for comparisons between the antibody and T-cell responses to select Ia determinants, but may also give important insights into the recognition of self Ia antigens.

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Factor-Mediated Regulation of the Expression of the H-2 Linked Low Molecular Weight Proteins (LMP)oncanavalin A stimulated T cells. This regulation is coordinate with the regulation of the level of both H-2 and Ia antigens in the same cell line, whereas the level of other cell surface molecules is unaffected.

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Book 1983application of sev- eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.

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鋪子

Ia Genes, Gene Products, and Determinantsmap within the I-A subregion, while E. maps to the I-E subregion. A. and E. genes code for a 34,000 dalton polypeptide while A. and E. genes code for a 28,000 dalton polypeptide. The noncovalent association of A.A. and E.E. form the I-A and I-E Ia molecules..Recent studies have confirmed the order o

exercise

Murine T Cell-Specific IA Antigens: Helper T Lymphocytes Express a Unique ,-Encoded Moleculeity complex (H-2) linked immune response (Ir) genes provide a model wherein the molecular basis for immune regulation can be examined (1). Cellular interactions, cell-mediated antiviral immunity, self-nonself discrimination, and immune suppression are H-2I region controlled traits (1).

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placebo-effect

漸強

Induction of Autoreactive T Cells by Stimulation Across the I-J Subregionsoluble T cell derived suppressor mediator (2) has stimulated a great deal of investigative work on this segment of chromosome (reviewed in 3,4). Determinants controlled by the I-J subregion and defined by alloantibody are expressed on 1) T cell subsets (Ly-l+,2.; Ly-l+,2+; Ly-l.,2+) and solubile me