Titlebook: Ion Channels as Targets in Drug Discovery; Gary Stephens,Edward Stevens Book 2024 The Editor(s) (if applicable) and The Author(s), under e

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Validation of TMEM16A Modulation as a Therapeutic Approach for the Treatment of Cystic Fibrosis: Thdeliver benefit. In this chapter we describe the discovery of a novel tool compound (ET002663), which effectively potentiates the activity of TMEM16A, and the studies undertaken to validate the concept of enhancing TMEM16A activity as a novel approach for the treatment of cystic fibrosis.

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Voltage-Gated Sodium Channels as Drug Targets in Epilepsy-Related Sodium Channelopathies,targeting VGSCs in the treatment of epilepsy-related sodium (Na) channelopathies. Notwithstanding significant technical hurdles, modulators of VGSCs are likely to remain a mainstay in the treatment of epilepsy-related channelopathies and epilepsy more generally.

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Therapeutic Targeting of Potassium Channels,onsequently, K. channels are validated drug targets for many of these disorders. The aim of the present chapter is to provide an overview of the therapeutic targeting of K. channels, paying attention to new developments in the field.

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