Titlebook: Iodine and the Brain; G. Robert DeLong,Jacob Robbins,Peter G. Condliffe Book 1989 Plenum Press, New York 1989 biology.brain.cortex.metabol

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A Neural Thyroid Hormone Receptor Genelogical effects. Generally, two mechanisms contribute to the particular variety of proteins synthesized either during development or in response to required physiological changes. On the one hand, specific DNA tertiary structure induced by associated nuclear proteins probably presets the transcripti

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Thyroid Hormone Regulation of Specific mRNAS in the Developing Brainain (1–7). In the human, disorders of maternal and fetal thyroid function include maternal and secondary fetal iodine deficiency, maternal hypothyroidism or hyperthyroidism, as well as disorders related to deficient fetal autonomous thyroid hormone secretion, i.e., goiter or sporadic congenital hypo

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Thyroid Influences on the Developing Cerebellum and Hippocampus of the Rat930’s (Kerley, 1936). Soon thereafter, animal studies were carried out which made clear the necessity of thyroid hormones for general somatic and neural development during the neonatal and early postnatal period in the rat, which is roughly equivalent to the first year of life in the human (Salmon,

Axon895

Microtubule Assembly: Regulation by Thyroid Hormones a hypothyroid animal is a “hypoplastic neuropil”. Eayrs (1), for instance, reported that thyroid hormone deficiency, when established at or before birth, reduces, in the cerebral cortex, the length and the branching of the dendrites of the pyramidal neurons, the density of the terminals and the num

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Investigation of Myelinogenesis in Vitro: Transient Expression of 3,5,3’-Triiodothyronine Nuclear Recognized for many years that most interfascicular oligodendrocytes of the white matter undergo massive membrane synthesis at myelination, leading to the formation and growth of myelin sheaths around axons in the CNS. Such oligodendrocytes probably subsequently maintain the integrity of myelin throug

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Developmental and Thyroid Hormone Regulation of Na,K-ATPase Isoforms in the Brainmaintains transmembrane cationic gradients by pumping three sodiums out of the cell for two potassiums into the cell fueled by ATP hydrolysis (1). The resultant electrochemical gradients are crucial for normal neuronal activity, and drive the transport of nutrients and reuptake of neurotransmitters

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Thyroid Hormones and Neurotransmitter Systems: An Interaction with Nerve Growth Factor in the Regulains of patients with an early abnormal thyroid state, and none of these studies gives information about the underlying biological mechanisms..For this, one has to turn to animal models. In the human foetus, thyroid function commences towards the end of the first trimester of pregnancy, whereas in ra

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Ontogeny of Thyroid Hormone-Processing Systems in Rat Brainat adult brain is unresponsive to thyroid hormones continues, at least in some quarters, to prevail. By contrast, a role for the hormone during brain development has, for some time, been assumed, even though observations suggesting a cause and effect relationship between triiodothyronine (T3) in the