Titlebook: Introduction to Evolutionary Genomics; Naruya Saitou Textbook 20131st edition Springer-Verlag London 2013 Bioinformatics.Bioinformatics.Ev

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A Brief History of Life reference to tRNAs, and estimation of the phylogenetic relationship of metabolic pathways before the diversification of prokaryotes and eukaryotes is given. The history of eukaryotes follows with special reference to multicellular lineages, finally reaching us human beings.

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Prokaryote Genomesuencing efforts, the basic structure of prokaryote genomes is discussed using . as an example, followed by discussions on GC content heterogeneity, horizontal gene transfer, codon usage, and plasmids. Finally, we discuss prokaryotic metagenomes.

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Genome Sequencingonstruction of genomic library and sequence determination. Computational tactics on determination of nucleotide sequences including base call, shotgun sequencing, minimum tiling array, haplotype sequence determination, and resequencing are also discussed.

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Evolutionary Distances substitutions including one-parameter method, two-parameter method, and methods incorporating observed nucleotide frequencies were explained in detail. Methods for estimating synonymous and nonsynonymous substitutions and amino acid substitutions were also discussed.

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Affiliation

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