Titlebook: Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems; Marc Thiriet Book 2013 Springer Science+Business Media New Y

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Introduction,s numerous, simultaneous or successive, events that result from permanent, regulated communications between it and adjoining cells and the extracellular matrix as well as remote controller cells of the nervous and endocrine systems, in addition to immunocytes. Cell signaling not only governs basic c

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Cytoplasmic Protein Tyrosine Kinases,signaling. They actually modulate multiple cellular events, such as differentiation, growth, metabolism, and apoptosis. On the other hand, protein serine/ threonine kinases are principally related to second messengers, such as cyclic nucleotides cAMP (Sect. 11.1) and cGMP (Sect. 11.2), lipidic and r

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Cytoplasmic Protein Serine/Threonine Kinases,ses), or as intermediate nodes of signaling cascades, . (intracellular; NRSTK) protein Ser/Thr kinases. Typically, second messengers activate protein Ser/Thr kinases, whereas extracellular signals stimulate protein Tyr kinases (Chap. 4). For example, IκB kinases (IKK) of IκB inhibitors of nuclear fa

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Dual-Specificity Protein Kinases, kinases intervene in the regulation of cell growth, differentiation, and apoptosis. Dual-specificity kinases include, at least, members of the superfamily of mitogen-activated protein kinases as well as those of the family of glycogen synthase kinases.

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Guanosine Triphosphatases and Their Regulators,mbrane receptors; (2) protein synthesis at the ribosome (Vol. 1 – .. Protein Synthesis); (3) control of cell division (Vol. 2 – .. Cell Growth and Proliferation); (4) proper protein folding; (5) translocation of proteins through the membrane of the endoplasmic reticulum; and (6) vesicular transport

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Other Major Types of Signaling Mediators, . (H.S; Sect. 10.4), in addition to . and ., as well as several . (ROS) and . (RNS; Sect. 10.6), that act as intra- and intercellular regulators; (2) membrane-bound enzymatic complexes such as the reduced form of . (NADPH oxidase or NOx; Sect. 10.5); (3) some ., such as (protein kinase) . (AKAP; Se

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Signaling Pathways,racellular calcium regulates numerous protein functions in tiny cellular domains ( < 1 μm) and small time scales ( < 1 ms). For example,Ca.1.2 channels form signaling clusters in plasmalemmal nanodomains. Fluorescence microscopy is aimed at imaging in real time communication within and between cells