Titlebook: Intracellular Signal Transduction: The JAK-STAT Pathway; Andrew F. Wilks,Ailsa G. Harpur Book 1996 Springer-Verlag Berlin Heidelberg 1996

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Book 1996tail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.

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Signal Transducers and Activators of Transcription: The STAT Proteins,ter 5 for a more detailed description). At present, six mammalian members of the STAT family are known, namely, STAT1. STAT2,. STAT3. also known as acute phase response factor (APRF),. STAT4,. STAT5 (also known as mammary gland factor [MGF]),. and IL-4-STAT. (also known as STAT-6).

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Book 1996y required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in de

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1431-0414 absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are cov

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Intracellular Signal Transduction,o chemical stimuli upon which they can make relevant developmental and functional decisions. For the purposes of this book, we will only address those issues which are pertinent to the intracellular signal transduction processes triggered by growth factors and cytokines. Our understanding of the mol

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The Cytokine Receptor Family,okine receptors. (Figs. 5-9). Class I comprises the cellular receptors for many interleukine (IL), such as those that regulate hematopoiesis, e.g., IL-3. IL-5, IL-11, granulocyte-macrophage colony stimulating factor (GM-CSF),. granulocyte-colony stimulating factor (G-CSF),. erythropoietin (EPO),. an

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Signal Transducers and Activators of Transcription: The STAT Proteins,locate to the nucleus where they interact with specific DNA sequences upstream of target genes (STAT-binding elements or SBEs) (Fig. 24; also see chapter 5 for a more detailed description). At present, six mammalian members of the STAT family are known, namely, STAT1. STAT2,. STAT3. also known as ac

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STFs: STAT-Containing Transcription Factors, elicited following stimulation of cytokine receptors and PTK receptors.. These STFs were originally revealed by dint of their ability to bind to specific DNA elements (known as STAT-binding elements or SBEs; see below), as demonstrated by electrophoretic mobility shift assays (EMSAs). Although ach

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