Titlebook: International Relations in the Anthropocene; New Agendas, New Age David Chandler,Franziska Müller,Delf Rothe Textbook 2021 The Editor(s) (i

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Rens van Munsterlife) can modulate offspring’s epigenome leading to tissue specific variations during cell differentiation processes, and may define epigenetic marks associated with long-term effects on offspring neuronal health. Being epigenetics reversible, a healthy diet represents a fundamental opportunity, eve

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Cheryl McEwanMultigeneration Study to address this issue. Mortality in G1 (N?=?9,565) was followed 1961–2015 and analysed by their parents’ (G0) age-at-death using Cox regression. For an almost entirely deceased segment of G1 (n?=?1,149), born 1915–1917, we compared exact age-at-death with G0 parents’ age-at-dea

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Olaf Corry,Nikolaj Kornbechility to several unfavorable outcomes later in life. It seems that these adversities induce adaptations, altering the metabolism to favor survival at critical periods, but at the expense of the individual’s health as a trade-off. These exposures increase the risk for non-transmittable diseases like

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Delf Rothe,Ann-Kathrin Bennerery rapid pace. Any perturbation to this process, either through nutritional insufficiency or exposure to endocrine disruptors or toxins, not only interrupts or delays the growth process, but in some cases results in metabolic abnormalities that challenge adult health. In terms of early childhood nu

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Dutch famine showed that babies with low birth weights had significantly higher obesity rates as adults. In several other studies, low birth weight has been correlated with development of type 2 diabetes (T2D), cardiovascular disease and obesity. Maternal diseases, such as hypertension and gestation

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Simon Dalbyhe lifecourse and evidence for transmission of these adverse disease traits to future generations. A key component underpinning this early life developmental programming is that of dysregulation of the growth hormone-insulin-like growth factor (GH-IGF) axis. Phenotypic outcomes in programmed offspri

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David Chandlerer, it is clear from findings in nonhuman species that adaptive plasticity during early development can have adverse consequences manifesting over the long-term in formation of the post-natal and adult phenotype, and that this occurs via partially characterized programming phenomena. Environmental e

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Cameron Harringtoning epidemic proportions in some sectors of the community and is often found in association with the two most characterised adult onset diseases, hypertension and noninsulin dependent diabetes mellitus. Epidemiological studies in humans have identified various maternal states such as anemia, diabete