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Titlebook: Interferons and Their Applications; Paul E. Came,William A. Carter (Professor and Dire Book 1984 Springer-Verlag Berlin Heidelberg 1984 Hi

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書目名稱Interferons and Their Applications
編輯Paul E. Came,William A. Carter (Professor and Dire
視頻videohttp://file.papertrans.cn/472/471003/471003.mp4
叢書名稱Handbook of Experimental Pharmacology
圖書封面Titlebook: Interferons and Their Applications;  Paul E. Came,William A. Carter (Professor and Dire Book 1984 Springer-Verlag Berlin Heidelberg 1984 Hi
描述Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances. Many also feel these polypeptides will prove invaluable probes in unraveling certain fundamental biochemical processes which control the life cycle and developmental pattern of many human cells. In contrast, only a year or two ago, this optimism had given way to an attitude almost of disenchantment as public and scientific expectations were raised steeply, then rapidly waned, as it turns out, prematurely. Both the mUltiple actions of interferons (a virtual cascade of biochemical reactions may be induced, as documented herein) and the high visibility of interferon research provided by the millions of dollars invested both by national health agencies and by multinational pharmaceutical companies, contributed to an upsweep in public attention to drug development probably unprecedented in this century. Virtually every oncologist, it would seem, was plagued by requests for the experimental agent, although they already had therapies of more proven value. As recently as 1980, even though
出版日期Book 1984
關(guān)鍵詞Histamin; Hormone; Insulin; Prostaglandin; Vitamin A; antibody; antigen; cancer; chromatography; hepatitis; in
版次1
doihttps://doi.org/10.1007/978-3-642-69178-2
isbn_softcover978-3-642-69180-5
isbn_ebook978-3-642-69178-2Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1984
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Application of Recombinant DNA Technology to Expression of Human Interferon Genes,mbinant DNA (rDNA) technology to IFN production. In addition to allowing the production of pure IFN in copious quantity, experimental use of cloned IFN genes has generated fundamental information which has radically altered our conception of IFN’s physiologic role and has explained apparent contradictions within the literature.
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0171-2004 c regarding the future of interferons as therapeutic substances. Many also feel these polypeptides will prove invaluable probes in unraveling certain fundamental biochemical processes which control the life cycle and developmental pattern of many human cells. In contrast, only a year or two ago, thi
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Comparative Structures of Mammalian Interferons,e.g., disulfide bond analysis and circular dichroism spectroscopy. Studies aimed at determining the composition and structure of the carbohydrate moiety of interferon are, of course, dependent upon the availability of naturally derived material, and thus have been more limited.
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Lymphoblastoid Interferon: Production and Characterization,d not provide enough cells to make interferon in really large amounts. Furthermore, only limited quality control procedures can be applied to individual white blood cell lots, and for example there are few countries where the incidence of hepatitis in blood donors is as low as in Finland.
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Fibroblast Interferons: Production and Characterization, se was not a homogeneous substance. This has made the interpretation of most of the early work on interferons quite difficult, as it is not evident what type, or types, of interferons were being worked with.
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