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Titlebook: Interferon: The Dawn of Recombinant Protein Drugs; J. Lindenmann,W.-D. Schleuning Conference proceedings 1999 Springer-Verlag Berlin Heide

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發(fā)表于 2025-3-21 18:45:55 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Interferon: The Dawn of Recombinant Protein Drugs
編輯J. Lindenmann,W.-D. Schleuning
視頻videohttp://file.papertrans.cn/471/471000/471000.mp4
叢書名稱Ernst Schering Foundation Symposium Proceedings
圖書封面Titlebook: Interferon: The Dawn of Recombinant Protein Drugs;  J. Lindenmann,W.-D. Schleuning Conference proceedings 1999 Springer-Verlag Berlin Heide
描述Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac- teriology and virology, and deputy director of the National Institute for Medical Research in London. When researchers are faced with a seemingly new phenomenon, ex- planations are easy to come by. These explanations fall into two broad categories: the phenomenon in question is either due to something or to the lack of something. I apologize for the primitive way in which I ex- press this, but I am going to give three examples, scattered over 100 years, of what I mean. First example: in 1880 the great French microbiologist Louis Pas- teur was involved in work on chicken cholera. He was struck by the following observation: if a suitable chicken broth was inoculated with the bacterium, the organism grew profusely and the liquid became tur- bid. If he now freed the fluid, by sedimentation or filtration, from the bulk of the organisms and re-inoculated it with the same bacterium, no growth
出版日期Conference proceedings 1999
關(guān)鍵詞Multiple Sclerosis; Protein Drugs; cancer; cancer therapy; cytokine; cytokines; interferon; protein; protein
版次1
doihttps://doi.org/10.1007/978-3-662-03787-4
isbn_softcover978-3-662-03789-8
isbn_ebook978-3-662-03787-4Series ISSN 0947-6075
issn_series 0947-6075
copyrightSpringer-Verlag Berlin Heidelberg 1999
The information of publication is updating

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發(fā)表于 2025-3-21 23:18:03 | 只看該作者
,The Clinical and Social Impact of Interferon-β: The First Approved Therapy in Multiple Sclerosis,. In this review I will examine the natural history of the disease in order for the reader to understand the difficulties associated with the care of patients with MS and in identifying new therapies for the disease. I will then discuss the impact of that approval and the current thoughts on treatment MS.
板凳
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地板
發(fā)表于 2025-3-22 07:42:24 | 只看該作者
0947-6075 er Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac- teriology and virology, and deputy director of the National Institute for Medical Research in London. When researchers are faced with a see
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發(fā)表于 2025-3-22 12:16:44 | 只看該作者
,What Constitutes Therapeutic Success? The Interferons (1978–1998), exaggerated coverage in the media, high public expectations, widespread disappointment and loss of interest when the claims failed to materialize in large scale trials, researchers and administrators forced on the defensive. and finally there seems hardly any reason for continuation of research or for clinical application.
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,Interferon-α: From Pass Interference to Cytokine Networking,f the functions of IFN become appreciated, with discovery of its roles in cell growth regulation and immune modulation. This early stage of interferon research (and which, indeed continues today at a more mechanistic, molecular level) can be thought of as the “pass interference” stage of interferon research.
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發(fā)表于 2025-3-23 04:38:53 | 只看該作者
Is There Life Without Interferon?,arly in evolutionary time, and so early that one can reasonably suppose they have a very fundamental role in multicellular organisms. Figure 1 is adapted from one in a 1985 paper by Weissmann and colleagues [1], and shows that the primitive IFN-α and IFN-β genes had already separated many million ye
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