| 書目名稱 | Interferon Alpha-2: Pre-Clinical and Clinical Evaluation | | 副標(biāo)題 | Proceedings of the S | | 編輯 | Daniel L. Kisner,J. F. Smyth | | 視頻video | http://file.papertrans.cn/471/470996/470996.mp4 | | 叢書名稱 | Developments in Oncology | | 圖書封面 |  | | 描述 | Interferon alpha-2 is a genetically engineered, highly purified pharmaceutical agent that has undergone extensive phase I and phase II clinical study in more than 1000 patients. The material has biological activity by intravenous, intramus- cular and subcutaneous routes. Clinical toxicity principally involves the ‘influen- za like‘ syndrome previously seen with native interferons. Other important toxi- cities include anorexia, hepatitis, confusion and myelosuppression. Tolerable doses in multiple schedules and routes of administration have been determined. Phase II clinical trials with multiple routes and schedules of administration have been performed. Significant clinical activity has been found in non- Hodgkin‘s lymphomas (both low grade and high grade), refractory and relapsing multiple myeloma, hairy cell leukemia, Kaposi‘s sarcoma, with suggestions of activity in Hodgkin‘s disease, renal cell carcinoma, and melanoma. The studies performed to date have for the most part involved small numbers of heavily pre-treated patients. Large-scale clinical trials in some of these disea- ses are now warranted in populations of patients with as little bulk disease and prior treatment as is | | 出版日期 | Conference proceedings 1985 | | 關(guān)鍵詞 | DNA; carcinoma; cell; clinical trial; interferon; leukemia; lymphoma; melanoma; ovarian cancer; renal cell ca | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4613-2579-6 | | isbn_softcover | 978-1-4612-9618-8 | | isbn_ebook | 978-1-4613-2579-6 | | copyright | Martinus Nijhoff Publishers, Boston 1985 |
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