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Titlebook: Integrins in Health and Disease; Key Effectors of Cel Donald Gullberg,Johannes A. Eble Book 2023 The Editor(s) (if applicable) and The Auth

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發(fā)表于 2025-3-21 18:04:58 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Integrins in Health and Disease
副標(biāo)題Key Effectors of Cel
編輯Donald Gullberg,Johannes A. Eble
視頻videohttp://file.papertrans.cn/470/469160/469160.mp4
概述Introduces the most important integrins and their biological functions.Discusses the role of integrins in tissue and tumor fibrosis.Explains the role of integrins as receptors for bacterial and viral
叢書名稱Biology of Extracellular Matrix
圖書封面Titlebook: Integrins in Health and Disease; Key Effectors of Cel Donald Gullberg,Johannes A. Eble Book 2023 The Editor(s) (if applicable) and The Auth
描述.Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis...This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the bookdiscusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion.?..Both experie
出版日期Book 2023
關(guān)鍵詞Integrins; Cell adhesion; Cell migration; Cell-extracellular matrix-signaling; Immunity; Intracellular in
版次1
doihttps://doi.org/10.1007/978-3-031-23781-2
isbn_softcover978-3-031-23783-6
isbn_ebook978-3-031-23781-2Series ISSN 0887-3224 Series E-ISSN 2191-1959
issn_series 0887-3224
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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發(fā)表于 2025-3-21 23:31:53 | 只看該作者
Integrins α1β1 and α2β1: The Generalist Collagen Receptorsknockout mouse models show no obvious developmental defects. Thus, α1β1 and α2β1 are not critical for organogenesis, but they can be considered as generalist integrins that have evolved to support and intensify processes driven by other receptors and proteins.
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α4 Integrins in Immune Homeostasis and Disease In this chapter, we summarize the major findings regarding α4 integrins over the last decades, including their structures, extracellular ligands, intracellular adaptor proteins, and functions in homeostasis and diseases, including cancer, multiple sclerosis (MS), inflammatory bowel disease (IBD), and other autoimmune diseases.
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發(fā)表于 2025-3-22 13:02:10 | 只看該作者
β2-integrins in Immunity: New Roles for Old Playerse, we describe their regulation, signaling, and mechanotransduction properties in immune cells. In addition, we describe their various functional roles in different immune cells, in host defense, infection, inflammatory diseases, and cancer.
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發(fā)表于 2025-3-22 19:59:44 | 只看該作者
0887-3224 the role of integrins as receptors for bacterial and viral .Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissu
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