Titlebook: Integrin Targeting Systems for Tumor Diagnosis and Therapy; Eleonora Patsenker Book 2018 Springer Science+Business Media, LLC, part of Spr

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1557-2153 serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research..978-1-4939-9247-8978-1-4939-7445-0Series ISSN 1557-2153 Series E-ISSN 1940-6053

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Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnroject: (1) the polymer and SPIO synthesis, (2) the physicochemical characterization of the nanoparticles, (3) the magnetic properties of the nanoparticles, and (4) the in vivo evaluation of the nanoparticles for their therapeutic and diagnosis purposes. We employ the electron spin resonance spectro

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Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal Doxorubicied for this project as follow: (1) preparation of peptide-modified PLDs, (2) characterization of colloidal properties and stability of PLDs, (3) in vitro cell interaction and cytotoxicity, and (4) in vivo biodistribution and therapeutic efficacy in mice bearing C-26 colon carcinoma tumor model.

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Preparation of Heterobivalent and Multivalent Radiopharmaceuticals to Target Tumors Over-Expressingpressing integrins and the radiation absorbed dose estimations to produce a therapeutic effect by Auger and low-energy electrons from .Tc internalized in cancer cell nuclei, as well as the effect of beta particles emitted from .Lu decay, were performed. In this chapter, the following protocols for t

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Integrin ,-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide,s can be attractive alternatives for image-guided drug delivery applications via integrin α.β.-mediated pathways. This chapter provides detailed protocols of how to produce luminescent ZnO nanomaterials (e.g., nanowires or nanoparticles) and use them at the cellular level for optical imaging of inte

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Integrin Targeting Using RGD-Based Peptide Amphiphiles,to outline methodologies used for the synthesis, characterization, and evaluation of these low-molecular-weight RGD-based micellar carriers for delivery of hydrophobic anticancer agents. The experimental details and factors to be considered for optimal methods are discussed.

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Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting, engineered nanocarrier systems have been shown to transport and deliver anticancer drugs more efficiently than the pristine drugs. Herein, we attempt to improve the therapeutic potential of DTX and to target the integrin receptor overexpressing angiogenic tumors, by encapsulating the DTX in nanomic

Vo2-Max

NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating lls or U87MG transplantation tumors could be eradicated by applying cRGD-IR-780 SLNs under the laser irradiation. Therefore, the resulted cRGD-IR-780 SLNs may serve as a promising NIR imaging-guided targeting PTT agent for cancer therapy. In this methodological chapter, we present the general flowch

Conspiracy

,Synergistic Active Targeting to B16F10 Tumors by αvβ3/CD44-Targeted Nanoparticles Loaded with Docetd in vivo through synergistic active-targeting function. This chapter gives an introduction to and discussion of the commonly used production and synthetic methods for tetrac conjugated HA and TeHA-SLNs/DTX. Moreover, the methods for characterization and cell targeting assessment in a αvβ3- and CD44