Titlebook: Insulin Resistance and Cancer; Epidemiology, Cellul I. George Fantus Book 2011 Springer Science+Business Media, LLC 2011 Hyperinsulinemia.I

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Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer,2]. Indeed, the fact that insulin has a potent tumor-promoting activity has been known for a long time. In wild-type animals, administration of exogenous insulin markedly enhances development of experimental breast and colon tumors [34, 68, 117]. In contrast, insulinopenia in animals with chemically

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Potential Mechanisms Linking Insulin to Cancer,r several cancers in both men and women, at least three primary cancers of women show this link, namely uterine, ovarian, and mammary cancers [11]. Previous chapters have reviewed the epidemiological data in detail. The focus of this chapter is to review and discuss the potential pathophysiology and

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Actions of Insulin As a Survival and Growth Factor: Akt, mTOR, and Regulation of Translation,vators of downstream pathways via the insulin receptor substrate (IRS) proteins. In a similar fashion, the insulin growth factor-1 receptor (IGF1R) transduces signals to downstream effectors via the PI3K and MAPK pathways.

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The Role of the IGF Axis in Human Malignancy: Evidence from Epidemiological Studies and Tissue Analor player in human cancer progression. This has led to a concerted effort to target the IGF axis, particularly the IGF-I receptor, for cancer therapy and has already resulted in the development of several inhibitors including insulin-like growth factor-I receptor (IGF-IR) antibodies and specific kin