Titlebook: Insights into Human Neurodegeneration: Lessons Learnt from Drosophila; Mousumi Mutsuddi,Ashim Mukherjee Book 2019 Springer Nature Singapor

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書目名稱Insights into Human Neurodegeneration: Lessons Learnt from Drosophila影響因子(影響力)




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Methods for Creating Fly Models to Understand the Molecular Mechanisms Underlying Neurological Diseutic remedies have become increasingly important. Such studies are contingent upon the availability of suitable model systems that recapitulate all the major hallmarks of these disorders?as seen in humans. As significant homology exists between humans and ., flies have proved to be one of the most s

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Understanding Motor Disorders Using Flies,netic engineering and the finding that 75% of genes that cause human disease have orthologs in the fly. Diseases of the human nervous system have been modeled extensively in the fly, taking advantage of a complex, well mapped out nervous system. A popular strategy to model a disease is to identify t

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,Metabolic Alterations Amalgamated with Huntington’s Disease,nown cure. Additionally, the concomitant occurrence of metabolic disturbances including unintended weight loss has also been reported in HD patients. However, the pathophysiology remains largely unclear. The underlying pathophysiology comes further complex due to the ubiquitous expression of the cau

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Notch Signaling: From Neurogenesis to Neurodegeneration,h has been shown to play a major role in cell fate determination, differentiation, proliferation and apoptotic events, as well as self-renewal processes of different tissues. The same pathway can be deployed in numerous cellular contexts to play varied and critical roles for the development of an or

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