Titlebook: Innovations in Antiviral Development and the Detection of Virus Infections; Timothy M. Block,Donald Jungkind,Lori R. Walsh Book 1992 The E

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Drugs as Molecular Tools, respectively. However, there is another scientific use for drugs or compounds which is to use them as molecular tools in the research laboratory in order to dissect the replication of viruses and to discover new facts about viruses. For example, alpha-amanitin, an inhibitor of the cellular DNA-depe

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Antiviral Agents from Novel Marine and Terrestrial Sources,f drugs through the years. Systematic searches for antiviral agents in nature, however, are both rare and recent. Our own extensive efforts to identify natural products with antiviral activity began with a one-month expedition to the Western Caribbean in 1978 on board the National Science Foundation

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,Virus Receptors: The Achilles’ Heel of Human Rhinoviruses,ognized serotypes that have been isolated and shown to be antigenically distinct (.). Similar to other picornaviruses, HRVs are non-enveloped viruses that contain four structural proteins, designated VP1, VP2, VP3, and VP4, which form a protein capsid with icosahedral symmetry. Within the viral caps

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Therapeutic Strategies Employing CD4, the HIV Receptor, glycoprotein (gp120) to CD4 molecules on the target cell membrane (.). Recombinant soluble forms of CD4 retain the capacity for high affinity binding to gp120 (.–.), suggesting potential therapeutic uses of CD4 derivatives. The diverse concepts for exploiting the CD4/gp120 interaction for therapy a

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Catalytic Antisense RNA (Ribozymes): Their Potential and Use as ANTI-HIV-1 Therapeutic Agents,dern science since it was the first demonstration that an informational molecule could also possess enzymatic activity, and hence changed our views on the possible origins of life. The discovery and characterization of the reactions carried out by RNA molecules has facilitated the development of an

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Therapies for Hepatitis B Virus: Current Status and Future Possibilities,lthough the chief burden of illness is felt in certain areas such as the Far East and sub-Saharan Africa, HBV is also a major cause of morbidity and mortality in the United States (.). Estimates by the Centers for Disease Control suggest that there are more than three hundred thousand new cases of a