Titlebook: Informing Clinical Practice in Nephrology; The Role of RCTs Mohsen El Kossi,Arif Khwaja,Meguid El Nahas Book 2015 Springer International Pu

Badger

Lupus Nephritis Clinical Trials: A Critical Appraisal,en very frustrating since no new treatment has been approved by regulatory authorities for the treatment of LN in over 60 years. Nevertheless, many randomized clinical trials have been designed and executed, and some have been instrumental in altering the landscape of “off-label” management of LN, p

GIST

ANCA-Associated Glomerulonephritis Clinical Trials: A Critical Appraisal,CA has been recognised in a range of small vessel vasculitides collectively as ANCA-associated vasculitis (AAV). AAV encompasses a number of clinical syndromes including granulomatosis with polyangitis (GPA formerly known as Wegener’s granulomatosis), microscopic polyangitis (MPA) and Churg-Strauss

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CAGE

Chronic Kidney Disease (CKD) Clinical Trials: A Critical Appraisal,[1], considerable research has focused on the understanding of the pathophysiology of chronic kidney disease (CKD). Numerous additional hypotheses and theories have been published, focusing on the key role of renal as well as extrarenal cells in the pathogenesis of progressive renal scarring and fib

PLAYS

Anemia in Chronic Kidney Disease Clinical Trials: A Critical Appraisal,delines by KDOQI in 1997. Since the introduction of erythropoietin to anaemia management in chronic kidney disease, there has been a continuous debate on the optimal haemoglobin target required to achieve the desirable clinical outcome whether in survival or quality of life. With the unequivocal evi

COWER

Lipids and Chronic Kidney Disease Clinical Trials: A Critical Appraisal,ic picture of cardiovascular disease differs between those on dialysis and patients with early stages of chronic kidney disease. Whilst atherosclerotic coronary artery disease is common in the early stages of CKD, arrhythmias, congestive cardiac failure and sudden cardiac death (SCD) prevail in ESRD

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柔美流暢

Diabetic Nephropathy Clinical Trials: A Critical Appraisal, ESRD. Worldwide, obesity and the associated type 2 diabetes mellitus (T2DM) have reached epidemic proportions leading to a significant rise in those suffering from diabetic kidney disease (DKD) [1]. This has coincided with considerable preclinical research aimed at a better understanding of the pat

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Primary Glomerular Disease Clinical Trials: A Critical Appraisal,tely, the quality of the studies encompassing this database has varied widely, in part due to difficulties in study design and subject enrolment. Many studies have been small and underpowered and have used surrogate endpoints, such as a change in proteinuria. Unintentional or unavoidable biases have

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